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Article

KPC-2 β-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate.

The Journal of biological chemistry - 1 Jan 2000

Mehta Shrenik C, Furey Ian M, Pemberton Orville A, Boragine David M, Chen Yu, Palzkill Timothy

Abstract excerpt

Serine active-site β-lactamases hydrolyze β-lactam antibiotics through the formation of a covalent acyl-enzyme intermediate followed by deacylation via an activated water molecule. Carbapenem antibiotics are poorly hydrolyzed by most β-lactamases owing to slow hydrolysis of the acyl-enzyme intermediate. However, the emergence of the KPC-2 carbapenemase has resulted in widespread resistance to these drugs,...

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Identifiers

PMID: 33273017
DOI: 10.1074/jbc.RA120.015050
PMCID: PMC7895804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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