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Article

Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance.

The Journal of biological chemistry - 1 Jan 2000

Tooke Catherine L, Hinchliffe Philip, Bonomo Robert A, Schofield Christopher J, Mulholland Adrian J, Spencer James

Abstract excerpt

Class A serine β-lactamases (SBLs) are key antibiotic resistance determinants in Gram-negative bacteria. SBLs neutralize β-lactams via a hydrolytically labile covalent acyl-enzyme intermediate. Klebsiella pneumoniae carbapenemase (KPC) is a widespread SBL that hydrolyzes carbapenems, the most potent β-lactams; known KPC variants differ in turnover of expanded-spectrum oxyimino-cephalosporins (ESOCs), for example,...

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Identifiers

PMID: 33257320
DOI: 10.1074/jbc.RA120.016461
PMCID: PMC7949053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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