Pharmacokinetics Screening, Molecular Docking, and Dynamics Simulations Revealed Novel Antimicrobial Peptide NKLF2 Mutants as Potent Inhibitors of Mycobacterium tuberculosis.

Abstract excerpt

The increasing threat of multidrug-resistant Mycobacterium tuberculosis (Mtb) underscores the urgent need for novel therapeutics that can circumvent existing resistance mechanisms. The clinical ineffectiveness of current treatment regimens propelled the exploration for alternative antimicrobials with minimal toxicity and multi-target specificity. This study aimed to design and optimize antimicrobial peptides...

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