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High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway

16 Jun 2017

Abstract excerpt

The main components of the quorum-sensing system are expected to be favorable targets for drug development to combat various chronic infectious diseases. ComA of Streptococcus is an ATP-binding cassette transporter containing a peptidase domain (PEP), which is essential for the quorum-sensing signal production. Using high-throughput screening, we found a potent small molecule that suppressed the S. mutans...

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Share to Antimicrobial Resistance in Staphylococcus
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PMID: 28642545
DOI: 10.1038/s41598-017-03567-2

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