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Article

Functional Variants of the RAD51 Gene Contribute to Susceptibility to Non-Syndromic Orofacial Clefts in a Han Chinese Population.

Orthodontics & craniofacial research - 1 Aug 2026

Guo Siyuan, Guo Tingting, Xu Yi, Chen Renji, Wang Xuejiu

Abstract excerpt

OBJECTIVES: Non-syndromic orofacial cleft (NSOFC) is a complex congenital disease caused by genetic and environmental factors, and its aetiology remains unclear. This study aims to investigate the association between potentially functional single-nucleotide polymorphisms (SNPs) in the RAD51 and E2F1 genes and the risk of developing NSOFC in the Han Chinese population. MATERIALS AND METHODS: A total of 200 NSOFC...

Topics

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Case-Control Studies
China
Cleft Lip
Cleft Palate
Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

E2F1 Transcription Factor

East Asian People

Rad51 Recombinase

Source

Open in PubMed Open full text

Identifiers

PMID: 41918261
DOI: 10.1111/ocr.70117
PMCID: PMC13485166

Genes

RAD51
E2F1
HNRNPA2B1
SFPQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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