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Article

The role of trans-acting factors in the pathogenesis of common psychiatric disorders.

Epigenetics - 1 Dec 2026

Peedicayil Jacob, Grayson Dennis R

Abstract excerpt

According to the omnigenic model for the inheritance of common traits proposed by Jonathan Pritchard's group in 2017, there are a very large number of genetic variants underlying common traits spread across the genome. Causal variants are of two types: core genes that have direct roles in disease pathogenesis that contribute only a small amount to total heritability and peripheral genes that are much more in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41915782
DOI: 10.1080/15592294.2026.2644747
PMCID: PMC13048609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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