Article
Missing heritability of common diseases and treatments outside the protein-coding exome.
Human genetics - 1 Oct 2014
Sadee Wolfgang, Hartmann Katherine, Seweryn Michał, Pietrzak Maciej, Handelman Samuel K, Rempala Grzegorz A
Abstract excerpt
Genetic factors strongly influence risk of common human diseases and treatment outcomes but the causative variants remain largely unknown; this gap has been called the 'missing heritability'. We propose several hypotheses that in combination have the potential to narrow the gap. First, given a multi-stage path from wellness to disease, we propose that common variants under positive evolutionary selection...
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