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Article

Background selection in recombining genomes and its consequences for the maintenance of variation in complex traits.

Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2026

Li Xinyi, Berg Jeremy J

Abstract excerpt

Background selection (BGS)-the reduction of linked neutral diversity via the purging of deleterious mutations-is a pervasive force in genomic evolution. However, its impact on complex phenotypes remains poorly understood because classical theory treats fitness effects as fixed rather than emerging from a phenotype-to-fitness map. Here, we investigate the impact of BGS across three phenotypic selection frameworks:...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41915739
DOI: 10.1073/pnas.2513613123
PMCID: PMC13056065

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