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Article

A model for background selection in nonequilibrium populations.

Genetics - 3 Jun 2026

Barroso Gustavo V, Ragsdale Aaron P

Abstract excerpt

In many taxa, levels of genetic diversity vary along their genomes. The framework of background selection models this variation in terms of linkage to constrained sites, and recent applications have been able to explain a large portion of the variation in human genomes. However, these studies have also yielded conflicting results, stemming from two key limitations. First, existing models are inaccurate in a...

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Identifiers

PMID: 41875378
DOI: 10.1093/genetics/iyag081
PMCID: PMC13232757

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