Article

Transition from background selection to associative overdominance promotes diversity in regions of low recombination

2019-08-28

Abstract excerpt

<h4>Summary</h4> Linked selection is a major driver of genetic diversity. Selection against deleterious mutations removes linked neutral diversity (background selection, BGS, Charlesworth et al. 1993), creating a positive correlation between recombination rates and genetic diversity. Purifying selection against recessive variants, however, can also lead to associative overdominance (AOD, Ohta 1971, Zhao & Charle...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 319189a9-c53e-5b70-90c0-1f654d417df5
DOI: 10.1101/748004

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transition from background selection to associative overdominance promotes diversity in regions of low recombinationDOI 10.1101/748004Read

Transition from Background Selection to Associative Overdominance Promotes Diversity in Regions of Low Recombination.Semantic proximity Read

Background selection from unlinked sites causes non-independent evolution of deleterious mutationsSemantic proximity Read

Background Selection From Unlinked Sites Causes Nonindependent Evolution of Deleterious Mutations.Semantic proximity Read

Background selection in recombining genomes and its consequences for the maintenance of variation in complex traitsSemantic proximity Read

Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements.Semantic proximity Read

Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elementsSemantic proximity Read

Patterns of genetic variability in genomic regions with low rates of recombinationSemantic proximity Read

A model for background selection in nonequilibrium populations.Semantic proximity Read

Natural selection at linked sites in humans.Semantic proximity Read

Genetic Variation: Harmful Recessive Mutations Have Unexpected Effects on Variation.Semantic proximity Read

A model for background selection in non-equilibrium populationsSemantic proximity Read

A New Model of Genetic Variation and Evolution Evaluates Relative Impacts of Background Selections and Selective SweepsSemantic proximity Read