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Article

Transition from Background Selection to Associative Overdominance Promotes Diversity in Regions of Low Recombination.

Current biology : CB - 6 Jan 2020

Gilbert Kimberly J, Pouyet Fanny, Excoffier Laurent, Peischl Stephan

Abstract excerpt

Linked selection is a major driver of genetic diversity. Selection against deleterious mutations removes linked neutral diversity (background selection [BGS]) [1], creating a positive correlation between recombination rates and genetic diversity. Purifying selection against recessive variants, however, can also lead to associative overdominance (AOD) [2, 3], due to an apparent heterozygote advantage at linked...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31866368
DOI: 10.1016/j.cub.2019.11.063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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