Article
CYP2C19 as a key enzyme in the metabolism of cantharidin in Huh-7 cells and mice.
Archives of toxicology - 1 Jul 2026
Zhang Jie, Lyu Feng, Tian Tongtong, Ma Jinghong, Liu Yijia, Wu Yifan, Song Kaiyin, Zhou Xiaowei, Wang Qing K, Yao Yufeng, Liu Liang
Abstract excerpt
Cantharidin (CTD), a traditional Chinese medicinal with a long history of use, exhibits broad-spectrum antitumor properties. However, its clinical application is severely limited by its inherent toxicity. Cytochrome P450 (CYP) enzymes are major phase I drug-metabolizing enzymes in clinical settings. To date, however, no enzymes responsible for the metabolism of CTD have been reported yet. In this study, specific...
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