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Article

Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11β-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778.

British journal of clinical pharmacology - 1 Jan 2018

Cheng Yaofeng, Wang Lifei, Iacono Lisa, Zhang Donglu, Chen Weiqi, Gong Jiachang, Humphreys William Griffith, Gan Jinping

Abstract excerpt

AIMS: BMS-823778 is an inhibitor of 11β-hydroxysteroid dehydrogenase type-1, and thus a potential candidate for Type 2 diabetes treatment. Here, we investigated the metabolism and pharmacokinetics of BMS-823778 to understand its pharmacokinetic variations in early clinical trials. METHODS: The metabolism of BMS-823778 was characterized in multiple in vitro assays. Pharmacokinetics were evaluated in healthy...

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Identifiers

PMID: 28850715
DOI: 10.1111/bcp.13421
PMCID: PMC5736839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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