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Article

NBL1 associates with renal phenotypes in mice, but partial Nbl1 reduction does not ameliorate kidney disease.

American journal of physiology. Renal physiology - 1 May 2026

Willey Courtney N, Bufi Rei, Takemon Yuka, Brackett Abigail, Warren Alicia, Spellacy Samantha, Gatti Daniel M, Sheehan Susan, Korstanje Ron

Abstract excerpt

Increased concentrations of neuroblastoma suppressor of tumorigenicity 1 (NBL1) in the blood have been associated with disease progression in diabetic kidney disease (DKD) and IgA nephropathy. However, it is unclear whether NBL1 is a causal factor for kidney disease and what is driving these increased concentrations in the blood. To test this, we evaluated Nbl1 heterozygous knockout (Nbl1+/-) mice in two models...

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Source

Identifiers

PMID: 41910154
DOI: 10.1152/ajprenal.00465.2025

Genes

NBL1
ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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