Article

YAP restricts renal inflammation and mitigates kidney damage in nephronothisis related kidney disease

2022-01-18

Abstract excerpt

<h4>ABSTRACT</h4> Nephronophthisis (NPH) is an orphan recessive kidney disease mostly caused by mutations in NPHP1 and 20 other genes encoding proteins that localize to primary cilia. To date the pathways linking altered primary cilia function to progressive kidney scarring in NPH remain poorly defined and therapeutic options allowing NPH patients to escape end-stage kidney disease are lacking. Distinct protein...

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Literature Corpus work: a0396b2e-0f5f-5be1-9581-68748a14b7e0
DOI: 10.1101/2022.01.17.475784

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