Article
Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease.
Scientific reports - 10 Jun 2020
Refaeli Ido, Hughes Michael R, Wong Alvin Ka-Wai, Bissonnette Mei Lin Z, Roskelley Calvin D, Wayne Vogl A, Barbour Sean J, Freedman Benjamin S, McNagny Kelly M
Abstract excerpt
Dominant and recessive mutations in podocalyxin (PODXL) are associated with human kidney disease. Interestingly, some PODXL mutations manifest as anuria while others are associated with proteinuric kidney disease. PODXL heterozygosity is associated with adult-onset kidney disease and podocalyxin shedding into the urine is a common biomarker of a variety nephrotic syndromes. It is unknown, however, how various...
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