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Article

Deciphering the genetic underlying causes of sex differences in multiple myeloma incidence and mortality.

HGG advances - 9 Jul 2026

Opakunle Ajibola, Shan Yuting, Huang Yingbo, Printzis Christina, Stanhope Catherine Therese, Stranger Barbara E, Huang Rong Stephanie

Abstract excerpt

Multiple myeloma (MM) is a genetically complex cancer that has a higher incidence and mortality in males when compared to females. These sex differences are well documented epidemiologically, yet their biological mechanisms remain uncharacterized. We hypothesized that sex-specific genetic regulation by somatic mutations affects MM cell gene expression differently in each sex and subsequently leads to differential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41902400
DOI: 10.1016/j.xhgg.2026.100596
PMCID: PMC13122808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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