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Sofosbuvir Suppresses the Genome Replication of DENV1 in Human Hepatic Huh7 Cells

7 Feb 2024

Abstract excerpt

Dengue virus (DENV) causes dengue fever and dengue hemorrhagic fever, and DENV infection kills 20,000 people annually worldwide. Therefore, the development of anti-DENV drugs is urgently needed. Sofosbuvir (SOF) is an effective drug for HCV-related diseases, and its triphosphorylated metabolite inhibits viral RNA synthesis by the RNA-dependent RNA polymerase (RdRp) of HCV....

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PMID: 38396699
DOI: 10.3390/ijms25042022

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