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Web-Based User Interface for Fam3PRO: A Multigene, Multicancer Risk Prediction Model for Families With Cancer History.

JCO clinical cancer informatics - 1 Mar 2026

Chen Xueying, Ke Jianfeng, Flynn Lauren, Parmigiani Giovanni, Braun Danielle

Abstract excerpt

PURPOSE: Hereditary cancer risk is key to guiding screening and prevention strategies. Cancer risks can vary by individual because of the presence or absence of high- and moderate-risk pathogenic variants (PVs) in cancer-associated genes, in addition to sex, age, and other risk factors. We previously developed Fam3PRO, a flexible multigene, multicancer Mendelian risk prediction model that estimates a patient's...

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PMID: 41894652
DOI: 10.1200/CCI-25-00332

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