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Article

Statistical methods for Mendelian models with multiple genes and cancers.

Genetic epidemiology - 1 Oct 2022

Liang Jane W, Idos Gregory E, Hong Christine, Gruber Stephen B, Parmigiani Giovanni, Braun Danielle

Abstract excerpt

Risk evaluation to identify individuals who are at greater risk of cancer as a result of heritable pathogenic variants is a valuable component of individualized clinical management. Using principles of Mendelian genetics, Bayesian probability theory, and variant-specific knowledge, Mendelian models derive the probability of carrying a pathogenic variant and developing cancer in the future, based on family...

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Identifiers

PMID: 35583099
DOI: 10.1002/gepi.22460
PMCID: PMC9452449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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