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Article

Evaluating a Mendelian Risk Prediction Model That Aggregates Across Genes and Cancers.

Genetic epidemiology - 1 Apr 2026

Liang Jane W, Idos Gregory E, Hong Christine, Shannon Kristen M, Bear Lauren M, Pichardo Jennifer Morales, Guan Zoe, McCarthy Anne Marie, Ford James M, Kurian Allison W, Gruber Stephen B, Braun Danielle, Parmigiani Giovanni

Abstract excerpt

Using principles of Mendelian genetics, probability theory, and mutation-specific knowledge, Mendelian risk prediction models identify those at high risk of carrying a heritable cancer susceptibility variant and assess future risk of cancer. Our previously-validated Fam3PRO model is a generalizable and computationally efficient Mendelian risk prediction framework that incorporates an arbitrary number of...

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Identifiers

PMID: 41793308
DOI: 10.1002/gepi.70038
PMCID: PMC13101823

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