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Article

Bioinformatics-based Mechanisms of Lipid Metabolism and Endoplasmic Reticulum Stress in Coronary Artery Disease.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Ye Lili, Ruan Huaiyu, Chen Qinyun, Chen Yiming, Wang Ruiyan, Zhou Jing, Wang Jian, He Mengyu, Wang Ke, Huang Yuli, Wang Feng

Abstract excerpt

INTRODUCTION: Lipid metabolism and endoplasmic reticulum stress (ERS) are crucial in coronary artery disease (CAD) pathogenesis, but the exact mechanisms remain unclear. This study aims to systematically investigate the molecular interplay between lipid metabolism and ERS in CAD. METHODS: Lipid metabolism-related genes (LRGs), ERS-related genes (ER-RGs), and the bulk RNA-seq dataset were collected related to CAD....

Read the complete abstract on PubMed

Topics

Humans
Lipid Metabolism
Coronary Artery Disease
Endoplasmic Reticulum Stress
Computational Biology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

NF-kappa B p50 Subunit

Phosphatidate Phosphatase

Gene Regulatory Networks

Machine Learning

Genetic Predisposition to Disease

Source

Identifiers

PMID: 41185499
DOI: 10.2174/0118715303432896251016035431

Genes

CAD
NFKB1
LPIN1
SEC24B
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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