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Proof of Concept for Tumor Mutational Burden Prediction Through Biophysical Analysis Based on UHF-Dielectrophoresis.

Biosensors - 25 Feb 2026

Daverat Héloïse, Blasco Nina, Robert Sandrine, Rovini Amandine, Dalmay Claire, Lalloué Fabrice, Pothier Arnaud, Durand Karine, Naves Thomas

Abstract excerpt

Tumor Mutational Burden (TMB) is a critical biomarker used to determine patient eligibility for immunotherapy with immune checkpoint inhibitors. However, its gold-standard assessment via whole exome sequencing is limited by high costs, technical complexity, and lengthy processing times. To address these challenges, we investigated whether Ultra-High-Frequency (UHF) electromagnetic wave sensing could serve as an...

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Identifiers

PMID: 41892027
DOI: 10.3390/bios16030134
PMCID: PMC13023853

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