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Simultaneous BRAFV600E Protein and DNA Aberration Detection in Circulating Melanoma Cells Using an Integrated Multimolecular Sensor.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Wuethrich Alain, Dey Shuvashis, Koo Kevin M, Sina Abu A I, Trau Matt

Abstract excerpt

Liquid biopsy has emerged as the next generation target for diagnostics and therapeutic monitoring of many diseases including cancer. Liquid biopsy offers noninvasive analysis of aberrant biomolecular changes (e.g., aberrant protein expression, DNA mutation) which can provide crucial information on disease stages and therapy responses. As a diagnostically important biomarker for melanoma, the detection of the...

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PMID: 33704721
DOI: 10.1007/978-1-0716-1205-7_20

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