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Electric Field-Induced Release and Measurement (EFIRM): Characterization and Technical Validation of a Novel Liquid Biopsy Platform in Plasma and Saliva.

The Journal of molecular diagnostics : JMD - 1 Aug 2020

Tu Michael, Cheng Jordan, Chen Yi-Lin, Jea Wen-Chien, Chen Wan-Li, Chen Chien-Jung, Ho Chung-Liang, Huang Wei-Lun, Lin Chien-Chung, Su Wu-Chou, Ye Qianlin, Deignan Josh, Grody Wayne, Li Feng, Chia David, Wei Fang, Liao Wei, Wong David T W, Strom Charles M

Abstract excerpt

Electric field-induced release and measurement (EFIRM) is a novel, plate-based, liquid biopsy platform capable of detecting circulating tumor DNA containing EGFR mutations directly from saliva and plasma in both early- and late-stage patients with non-small-cell lung cancer. We investigated the properties of the target molecule for EFIRM and determined that the platform preferentially detects single-stranded DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32497715
DOI: 10.1016/j.jmoldx.2020.05.005
PMCID: PMC7416077

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