Article
Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.
Respiratory research - 7 Apr 2020
Carla Adrien, Pereira Bruno, Boukail Hanifa, Audard Jules, Pinol-Domenech Nathalie, De Carvalho Manuela, Blondonnet Raiko, Zhai Ruoyang, Morand Dominique, Lambert Céline, Sapin Vincent, Ware Lorraine B, Calfee Carolyn S, Bastarache Julie A, Laffey John G, Juffermans Nicole P, Bos Lieuwe D, Artigas Antonio, Rocco Patricia R M, Matthay Michael A, McAuley Daniel F, Constantin Jean-Michel, Jabaudon Matthieu
Abstract excerpt
BACKGROUND: Subphenotypes were recently reported within clinical acute respiratory distress syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models have long been used to mimic features of ARDS pathophysiology, but the presence of distinct subphenotypes among preclinical ARDS remains unknown. This review will investigate whether: 1) subphenotypes can be identified among preclinical...
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