Gas Plasma Exposure Attenuates the Inflammatory Rheumatoid Arthritis-Like Phenotype of Murine Synoviocytes in Vitro.

Abstract excerpt

Rheumatoid arthritis (RA) is driven by hyperplastic fibroblast-like synoviocytes (FLS) that adopt a persistent inflammatory and invasive phenotype, often resistant to conventional therapies. Here, we investigated whether cold gas plasma exposure modulates inflammatory FLS (iFLS) in vitro. Primary murine FLS were primed with TNF-α to induce an inflammatory phenotype and exposed to an argon plasma jet for 30-150 s;...

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• Arthritis, Rheumatoid
• Cell Survival
• Inflammation
• Intercellular Adhesion Molecule-1
• Interleukin-6