Article

Sublethal DNA Damage Switches Off B-Cell Effector Programs in an RA-FLS- PBMC Co-culture

2025-11-17

Abstract excerpt

<title>Abstract</title> <p>Rheumatoid arthritis (RA) features lymphocyte-driven inflammation in which B cells, alongside T cells, play key effector roles (autoantibody production, antigen presentation, cytokines, or chemokines). Within B cells, during normal diversification, activation-induced cytidine deaminase (AID) introduces targeted DNA lesions in immunoglobulin loci (class-switch recombination/somatic hyper...

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Literature Corpus work: cbdd6d2c-aab8-52fe-9fd3-3eed5d6190d7
DOI: 10.21203/rs.3.rs-7912272/v1

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Sublethal DNA Damage Switches Off B-Cell Effector Programs in an RA-FLS- PBMC Co-cultureDOI 10.21203/rs.3.rs-7912272/v1Read

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