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Article

Digital spatial profiling uncovers transcriptomic features of distinct plasma cell-like phenotypes in diffuse large B-cell lymphoma.

Blood advances - 9 Jun 2026

Xie Zucheng, Qin Yan, Xue Xuemin, Chen Xinrui, Xie Tongji, Zhu Haohua, Huang Liling, Yang Sheng, Yang Jianliang, Liu Peng, Gui Lin, Tang Le, Feng Xiaoli, Shi Yuankai

Abstract excerpt

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) exhibits marked heterogeneity, complicating treatment and prognosis. The role of plasma cell-like phenotypes in DLBCL remains underexplored. Using spatially resolved transcriptomics, we profiled 4 distinct plasma cell-like phenotypes in DLBCL based on CD20, HLA-DRA, and PR domain zinc finger protein 1 (PRDM1) markers: CD20+HLA-DRA+ PRDM1-, CD20+ HLA-DRA+ PRDM1+,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41886633
DOI: 10.1182/bloodadvances.2025018014
PMCID: PMC13241745

Genes

PRDM1
B2M

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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