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Article

Hydrophobic ice-binding sites confer hyperactivity of an antifreeze protein from a snow mold fungus.

The Biochemical journal - 1 Nov 2016

Cheng Jing, Hanada Yuichi, Miura Ai, Tsuda Sakae, Kondo Hidemasa

Abstract excerpt

Snow mold fungus, Typhula ishikariensis, secretes seven antifreeze protein isoforms (denoted TisAFPs) that assist in the survival of the mold under snow cover. Here, the X-ray crystal structure of a hyperactive isoform, TisAFP8, at 1.0 Å resolution is presented. TisAFP8 folds into a right-handed β-helix accompanied with a long α-helix insertion. TisAFP8 exhibited significantly high antifreeze activity that is...

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Source

Identifiers

PMID: 27613857
DOI: 10.1042/BCJ20160543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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