Article
Tumor vessel phenotype in colorectal cancer microenvironment according to age at diagnosis.
British journal of cancer - 1 May 2026
Matsuda Kosuke, Ugai Satoko, Miyahara Satoshi, Yao Qian, Cazaubiel Jules, Nakazawa Nobuhiro, Higashioka Mayu, Zhong Yuxue, Chan Andrew T, Meyerhardt Jeffrey A, Ng Kimmie, Song Mingyang, Väyrynen Juha P, Nowak Jonathan A, Giannakis Marios, Ugai Tomotaka, Ogino Shuji
Abstract excerpt
BACKGROUND: Given the global issue of the rising incidence of early-onset colorectal cancer (CRC), we tested the hypothesis that tumor vasculature phenotypes might vary with age at CRC diagnosis. METHOD: We used in situ multispectral immunofluorescence combined with digital image analysis and machine learning to measure expression of endothelial cell markers [ACKR1 (DARC), CD34, CD36, KDR (VEGFR2), LAMB1 (laminin...
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