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Article

Distantly metastatic differentiated thyroid carcinoma is kinase-driven and enriched for DNA repair and DNA methylation gene alterations.

The Journal of pathology - 1 Jul 2026

Kong Weimao, Bao Longnv, Hu Jianxia, Li Guangqi, Liu Yixuan, Ran Wenwen, Zhang Tingling, Gu Haiyan, Zhang Xinyi, Wang Meili, Ji Hong, Zong Xuzhang, Zhang Yongsheng, Dang Shouqin, Li Dong, Fa Liangling, Yu Xunzong, Pan Xingzhu, Li Xueqing, Wang Jigang

Abstract excerpt

Although distant metastasis is uncommon in differentiated thyroid carcinoma (DTC), it remains the leading cause of thyroid cancer-related mortality. The genetic landscape of distantly metastatic DTC (DMDTC) has not been well characterized in large cohorts. This study aimed to identify functional genetic alterations in DMDTC and validate their biological significance. We included 78 patients with DMDTC and...

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Source

Identifiers

PMID: 41881819
DOI: 10.1002/path.70052

Genes

DNMT3A
ALK
BRAF
PTEN
RFTN1
SPON1
STK11
BNC2
DAPK1
FLNC
HMGB2
SLC12A7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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