Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty.

doi:10.1371/journal.pntd.0003404

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Article

Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty.

PLoS neglected tropical diseases - 1 Jan 2015

Carnes Jason, Anupama Atashi, Balmer Oliver, Jackson Andrew, Lewis Michael, Brown Rob, Cestari Igor, Desquesnes Marc, Gendrin Claire, Hertz-Fowler Christiane, Imamura Hideo, Ivens Alasdair, Kořený Luděk, Lai De-Hua, MacLeod Annette, McDermott Suzanne M, Merritt Chris, Monnerat Severine, Moon Wonjong, Myler Peter, Phan Isabelle, Ramasamy Gowthaman, Sivam Dhileep, Lun Zhao-Rong, Lukeš Julius, Stuart Ken, Schnaufer Achim

Abstract excerpt

Two key biological features distinguish Trypanosoma evansi from the T. brucei group: independence from the tsetse fly as obligatory vector, and independence from the need for functional mitochondrial DNA (kinetoplast or kDNA). In an effort to better understand the molecular causes and consequences of these differences, we sequenced the genome of an akinetoplastic T. evansi strain from China and compared it to the...

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PMID: 25568942
DOI: 10.1371/journal.pntd.0003404
PMCID: PMC4288722

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