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Article

Structural Constraints Acting on the SARS-CoV-2 Spike Protein Reveal Limited Space for Viral Adaptation.

Genome biology and evolution - 2 Mar 2026

Herzig James C, Magwira Michael L, Lovell Simon C

Abstract excerpt

The SARS-CoV-2 pandemic resulted in an unprecedented scientific response. The scale of global genome sequencing, protein structural determination, and targeted studies of variant dynamics has resulted in a unique dataset, providing a valuable resource for studying viral evolutionary dynamics. Previous analysis of SARS-CoV-2 evolution has revealed apparently saltatory dynamics, with viral variants arising...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 41876430
DOI: 10.1093/gbe/evag049
PMCID: PMC13012802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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