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Article

Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics.

eLife - 7 May 2024

Ose Nicholas James, Campitelli Paul, Modi Tushar, Kazan I Can, Kumar Sudhir, Ozkan Sefika Banu

Abstract excerpt

We integrate evolutionary predictions based on the neutral theory of molecular evolution with protein dynamics to generate mechanistic insight into the molecular adaptations of the SARS-COV-2 spike (S) protein. With this approach, we first identified candidate adaptive polymorphisms (CAPs) of the SARS-CoV-2 S protein and assessed the impact of these CAPs through dynamics analysis. Not only have we found that CAPs...

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Identifiers

PMID: 38713502
DOI: 10.7554/eLife.92063
PMCID: PMC11076047

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