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Article

From single-sequences to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2.

Nature communications - 19 Feb 2026

Lamb Kieran D, Hughes Joseph, Lytras Spyros, Young Francesca, Koci Orges, Herzig James C, Lovell Simon C, Grove Joe, Yuan Ke, Robertson David L

Abstract excerpt

Protein language models (PLMs) capture features of protein three-dimensional structure from amino acid sequences alone, without requiring multiple sequence alignments (MSA). The concepts of grammar and semantics from natural language have been suggested to have the potential to capture functional properties of proteins. Here, we investigate how these representations enable assessment of variation due to mutation....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41714330
DOI: 10.1038/s41467-026-69569-9
PMCID: PMC13031934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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