Article
Mapping the Evolutionary Space of SARS-CoV-2 Variants to Anticipate Emergence of Subvariants Resistant to COVID-19 Therapeutics.
PLoS computational biology - 1 Jun 2024
Rojas Chávez Roberth Anthony, Fili Mohammad, Han Changze, Rahman Syed A, Bicar Isaiah G L, Gregory Sullivan, Helverson Annika, Hu Guiping, Darbro Benjamin W, Das Jishnu, Brown Grant D, Haim Hillel
Abstract excerpt
New sublineages of SARS-CoV-2 variants-of-concern (VOCs) continuously emerge with mutations in the spike glycoprotein. In most cases, the sublineage-defining mutations vary between the VOCs. It is unclear whether these differences reflect lineage-specific likelihoods for mutations at each spike position or the stochastic nature of their appearance. Here we show that SARS-CoV-2 lineages have distinct evolutionary...
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