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Article

The interplay of SARS-CoV-2 evolution and constraints imposed by the structure and functionality of its proteins.

PLoS computational biology - 1 Jul 2021

Jaroszewski Lukasz, Iyer Mallika, Alisoltani Arghavan, Sedova Mayya, Godzik Adam

Abstract excerpt

The unprecedented pace of the sequencing of the SARS-CoV-2 virus genomes provides us with unique information about the genetic changes in a single pathogen during ongoing pandemic. By the analysis of close to 200,000 genomes we show that the patterns of the SARS-CoV-2 virus mutations along its genome are closely correlated with the structural and functional features of the encoded proteins. Requirements of...

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Identifiers

PMID: 34237054
DOI: 10.1371/journal.pcbi.1009147
PMCID: PMC8291704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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