Pathophysiology of SPINK mutations in pancreatic development and disease.

doi:10.1016/j.ecl.2006.02.012

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Article

Pathophysiology of SPINK mutations in pancreatic development and disease.

Endocrinology and metabolism clinics of North America - 1 Jun 2006

Liddle Rodger A

Abstract excerpt

The endogenous pancreatic trypsin inhibitor, SPINK, is believed to limit enzyme activity in the pancreas and reduce the risk of pancreatitis. Recently, mutations in the SPINK1 gene have been associated with development of both acute and chronic pancreatitis. In most patients with SPINK1 mutations, the genetic variants do not cause the disease independently, but may act in concert with other genetic or...

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Share to Carrier Proteins
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Identifiers

PMID: 16632097
DOI: 10.1016/j.ecl.2006.02.012

Genes

SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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