Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer

14 Sept 2019

Abstract excerpt

BACKGROUND: Previous studies revealed somatic mutations of the cationic trypsinogen gene (PRSS1) in patients with chronic pancreatitis and pancreatic cancer. However, whether PRSS1 mutations trigger pancreatic cancer and/or promote malignant proliferation and metastasis in pancreatic cancer remains largely unclear, as well as the potential underlying mechanisms. METHODS: In the present study, whole-exome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pancreatic and Hepatic Oncology Research
Share to Pancreatitis Pathology and Treatment
Share to Skin and Cellular Biology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31521106
DOI: 10.1186/s10020-019-0111-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancerPMID 31521106Read ↗

Novel mutations of PRSS1 gene in patients with pancreatic cancer among Han population.Semantic proximity Read ↗

Spink1 promotes the survival of Kras-mutant pancreatic acinar cells.Semantic proximity Read ↗

From somatic mutation to early detection: insights from molecular characterization of pancreatic cancer precursor lesions.Semantic proximity Read ↗

Genetic Abnormalities in Pancreatitis: An Update on Diagnosis, Clinical Features, and TreatmentSemantic proximity Read ↗

International consensus guidelines on surveillance for pancreatic cancer in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.Semantic proximity Read ↗

Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitisSemantic proximity Read ↗

The -409 C/T genotype of PRSS1 protects against pancreatic cancer in the Han Chinese population.Semantic proximity Read ↗

PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer.Semantic proximity Read ↗

Hereditary Pancreatitis in the United States: Survival and Rates of Pancreatic Cancer.Semantic proximity Read ↗

Pancreatic intraepithelial neoplasia is associated with chronic pancreatitis due to serine protease inhibitor kazal type 1 and cystic fibrosis transmembrane conductance regulator mutations.Semantic proximity Read ↗

Genetics and clinical implications of SPINK1 in the pancreatitis continuum and pancreatic cancer.Semantic proximity Read ↗

Histopathological features of patients with chronic pancreatitis due to mutations in the PRSS1 gene: evaluation of BRAF and KRAS2 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.