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Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP

2 Sept 2023

Abstract excerpt

Aging-related diseases are closely associated with the state of inflammation, which is known as “inflammaging.” Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed the senescence-associated secretory phenotype (SASP). Epigenetic regulation, especially the structural regulation of chromatin, is closely linked to the...

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PMID: 37666472
DOI: 10.1016/j.mad.2023.111868

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