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Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice

16 Jul 2024

Abstract excerpt

The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 participants were recruited for the screening of differentially expressed plasma microRNAs (miRNAs). We found that miR-1204 is significantly increased in both the plasma and aorta of elder patients with AAD and is positively correlated with age. Cell senescence induces the expression of miR-1204 through p53...

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PMID: 39013850
DOI: 10.1038/s41467-024-50036-2

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