[Multi-strategy modification for constructing an engineered strain with efficient production of O-acetyl- l-homoserine].

Abstract excerpt

O-acetyl- l- homoserine (OAH) is a key intermediate in the synthesis of various high-value compounds such as l-methionine and has a high market value. However, the production of OAH still faces problems such as low yields and long fermentation periods. In this study, the wild type of the probiotic Escherichia coli Nissle 1917 (EcN) was used as the starting strain. Firstly, we obtained the mutant...

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