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Article

PCSK9 and Breast Cancer Survival: A Mendelian Randomization Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Jun 2026

Pott Janne, Mason Amy M, Salo Ville, Kettunen Johannes, Burgess Stephen

Abstract excerpt

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects lipid metabolism. A recent study identified an association between rs562556 within the PCSK9 gene and breast cancer survival (BCS), suggesting PCSK9 inhibition as an early intervention strategy to prevent metastasizing breast cancer. We attempt to replicate these findings using genome-wide association study (GWAS) data and Mendelian...

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Identifiers

PMID: 41870236
DOI: 10.1158/1055-9965.EPI-25-1569
PMCID: PMC13227093

Genes

PCSK9
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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