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Article

FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation

26 Oct 2022

Abstract excerpt

Acquired immunodeficiency syndrome (AIDS) cannot be completely cured, mainly due to the existence of a latent HIV-1 reservoir. However, our current understanding of the molecular mechanisms underlying the establishment and maintenance of HIV-1 latent reservoir is not comprehensive. Here, using a genome-wide CRISPR-Cas9 activation library screening, we identified E3 ubiquitin ligase F-box protein 34 (FBXO34) and...

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PMID: 36285453
DOI: 10.1080/22221751.2022.2140605

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