Article
Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers.
Clinical epigenetics - 2 Nov 2024
Van Asselt Austin J, Beck Jeffrey J, Finnicum Casey T, Johnson Brandon N, Kallsen Noah, Viet Sarah, Huizenga Patricia, Ligthart Lannie, Hottenga Jouke-Jan, Pool René, der Zee Anke H Maitland-van, Vijverberg S J, de Geus Eco, Boomsma Dorret I, Ehli Erik A, van Dongen Jenny
Abstract excerpt
BACKGROUND: Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We investigated the relationship between DNA methylation and 35 clinical markers of asthma. METHODS: The Illumina Infinium EPIC v1 methylation array was used to evaluate 742,442 CpGs in whole blood from 319 participants from 94 families. They were part of the Netherlands Twin Register...
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