Article
Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures.
The ISME journal - 1 May 2021
Harrow Gabrielle L, Lees John A, Hanage William P, Lipsitch Marc, Corander Jukka, Colijn Caroline, Croucher Nicholas J
Abstract excerpt
Streptococcus pneumoniae can be divided into many strains, each a distinct set of isolates sharing similar core and accessory genomes, which co-circulate within the same hosts. Previous analyses suggested the short-term vaccine-associated dynamics of S. pneumoniae strains may be mediated through multi-locus negative frequency-dependent selection (NFDS), which maintains accessory loci at equilibrium frequencies....
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