Article
Neutral microepidemic evolution of bacterial pathogens.
Proceedings of the National Academy of Sciences of the United States of America - 8 Feb 2005
Fraser Christophe, Hanage William P, Spratt Brian G
Abstract excerpt
Understanding bacterial population genetics is vital for interpreting the response of bacterial populations to selection pressures such as antibiotic treatment or vaccines targeted at only a subset of strains. The evolution of transmissible bacteria occurs by mutation and localized recombination and is influenced by epidemiological as well as molecular processes. We demonstrate that the observed population...
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