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Aerobic Fitness and Health-Related Phenotypes: A Two-Stage Phenome-Wide Mendelian Randomization Study.

Medicine and science in sports and exercise - 1 Jul 2026

Fornara Eleonora, Hernández Marta H, Fernández-Sanlés Alba, Hernando-Redondo Javier, Camps-Vilaró Anna, Polo-Alonso Sara, Lassale Camille, Dégano Irene R, Elosua Roberto, Schröder Helmut, Marrugat Jaume, Hernáez Álvaro

Abstract excerpt

PURPOSE: We investigated potentially causal associations between genetically predicted aerobic fitness and multiple health phenotypes using a two-stage phenome-wide Mendelian randomization (MR) study. METHODS: Genetically determined aerobic fitness, as operationalized by Cai et al., served as the exposure instrument. We screened 712 health-related phenotypes as outcomes using publicly available European-ancestry...

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PMID: 41851812
DOI: 10.1249/MSS.0000000000003975
PMCID: PMC13215641

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