Article
Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts.
Scandinavian journal of medicine & science in sports - 1 May 2026
Joensuu L, Lukander V, Herranen P, Tynkkynen N P, Kujala U, Lopéz-Bueno R, Nordeidet A N, Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Ollikainen M, Sillanpää E
Abstract excerpt
We evaluated how much cardiorespiratory fitness (CRF)-related genetics contribute to the risk of common noncommunicable diseases (NCDs) and mortality, and whether individuals with different levels of CRF and genetic predispositions differ in health characteristics. We used a validated SBayesR-based genome-wide polygenic score, leveraging information from 905 707 single-nucleotide polymorphisms, to measure CRF...
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